| 摘要 |
A parenteral pharmaceutical formulation in suspension, for sustained release, containing suspended estradiol and progesterone particles for hormonal replacement in female mammals in low and ultra-low dose, in the form of an injectable suspension comprising estradiol particles, progesterone particles, a surfactant agent, an isosmotic agent, a viscous increasing agent and one or more preservatives, wherein: the low-dose formulation comprises between 0.5mg to 1.0mg of estradiol and between 20mg to 75mg of progesterone, and the ultra-low does formulation comprises 0.25 to 0.50mg of estradiol and 15.0mg of progesterone. The estradiol may be in particles having a size between 1 and 100 microns and the progesterone is in particles having a size between 1 and 100 microns and it may be for application thereof in parenteral, intramuscular, subcutaneous or intradermal pharmaceutical form. |
