发明名称 |
NOVEL PEPTIDE HYDROGELS GENERATING CHEMICAL EXCHANGE SATURATION TRANSFER MRI CONTRAST AND USES THEREOF |
摘要 |
The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions. |
申请公布号 |
WO2014176586(A1) |
申请公布日期 |
2014.10.30 |
申请号 |
WO2014US35651 |
申请日期 |
2014.04.28 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;KENNEDY KRIEGER INSTITUTE, INC.;NATIONAL INSTITUTES OF HEALTH |
发明人 |
MCMAHON, MICHAEL T.;CHAN, KANNIE WAI YAN;GIANO, MICHAEL CHRISTOPHER;OSKOLKOV, NIKITA;SCHNEIDER, JOEL PATRICK;SONG, XIAOLEI |
分类号 |
A61K49/06;A61K49/08;A61K49/14 |
主分类号 |
A61K49/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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