发明名称 |
Inhibitors of proteins specific for the secretome of a chondrocyte for use in the treatment of breast cancer metastasis |
摘要 |
The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof. |
申请公布号 |
EP2796875(A1) |
申请公布日期 |
2014.10.29 |
申请号 |
EP20130164922 |
申请日期 |
2013.04.23 |
申请人 |
ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG |
发明人 |
SHASTRI, PRASAD;CHRISTENSEN, JON |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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