主权项 |
1. A compound having the general formula Ia:wherein
m is 0, 1, 2, 3 or 4; n is 0, 1, 2, or 3; X, Y and Z are CH; R1 is, at each occurrence, independently selected from the group consisting of hydrogen, halogen, C1-C10 alkyl, C1-C3 haloalkyl, C3-C7 cycloalkyl, hydroxyl, oxo, —OR4, —C(O)OR4, —C(O)R4, —C(O)N(R4)2, —CN, —NO2, —NH2, —N(R4)2, —OR4HetA, —OR4N(R4)2, —C(O)N(R4)R4HetA, —C(O)N(R4)HetA, —C(O)HetA, —C(O)N(R4)R4S(O)2R4; —S(O)2N(R4)2, —S(O)2R4, —N(R4)C(O)R4SR4, —N(R4)R4S(O)2R4, —N(R4)S(O)2R4, —C(S)R4, aryl, benzyl, and heterocyclyl, any of which is optionally substituted; R2 is, at each occurrence, independently selected from the group consisting of hydrogen, halogen, C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl, C3-C10 cycloalkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, —OH, —OR5, C1-C10 alkoxy, C3-C10 cycloalkoxy, C3-C15 cycloalkylalkoxy, C3-C15 cycloalkylalkyl, —CN, —NO2, —NH2, —N(R5)2, —C(O)R5, —C(O)OR5, —C(O)N(R5)2, —SR5, —S(O)R5, —S(O)2R5, —S(O)2N(R5)2, aryl, benzyl, heteroaryl, and heterocyclyl, any of which is optionally substituted; R3 is, at each occurrence, independently selected from the group consisting of hydrogen, halogen, C1-C10 alkyl, C3-C10 cycloalkyl, hydroxyl, —OR6, —CN, —NO2, —NH2, —N(R6)C(O)R6, —C(O)R6, —C(O)OR6, —C(O)N(R6)2, —S(O)R6, —S(O)2R6, —S(O)2N(R6)2, aryl, benzyl, heteroaryl, heterocyclyl, any of which is optionally substituted, or two groups of R3 are connected to each other to make a five or six membered cyclic or heterocyclic ring, any of which is optionally substituted; R4 is, at each occurrence, independently selected from the group consisting of hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl, C3-C10 cycloalkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, —C(O)R7, —R7(R7)C(O)R7, —C(O)OR7, —R7(R7)C(O)OR7, —C(O)N(R7)2, —R7(R7)C(O)N(R7)2, —S(O)R7, —S(O)2R7, —S(O)2N(R7)2, aryl, benzyl, heteroaryl, and heterocyclyl, any of which is optionally substituted; and R5, R6 and R7 are, at each occurrence, independently selected from the group consisting of hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl, C3-C10 cycloalkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, aryl, benzyl, heteroaryl, and heterocyclyl, any of which is optionally substituted; and pharmaceutically acceptable salts thereof, and wherein the compound has a formula selected from the following formulae 5, 8, 13, 14, 17, 18, 20, 21, 23-43, 46, 48, 50, 51, 53, 59, 68, 69, 74, 79, 80, 89-91, 142, 143, 161, 196, 211-213, 219, 221, 222, 239-247, 264, 313-329 and 331: 2-Methyl-N-(pyridin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (5) N-Benzyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide (8) 2-Methyl-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide (13) 2-Methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide (14) N-((1H-Indo)-5-yl)methyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide (17) N—(Cyclohexylmethyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide (18) 2-Methyl-N-(piperidin-4-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide (20) 2-Methyl-N-phenethylimidazo[1,2-a]pyridine-3-carboxamide (21) 2-Methyl-N-(2-phenoxyethyl)imidazo[1,2-a]pyridine-3-carboxamide (23) N-(2-(Benzyloxy)ethyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide (24) (S)-Methyl 2-(2-methylimidazo[1,2-a]pyridine-3-carboxamido)-3-phenylpropanoate (25) N-(2-Methylimidazo[1,2-a]pyridin-3-yl)-2-phenylacetamide (26) N-Benzyl-8-chloro-2-methylimidazo[1,2-a]pyridine-3-carboxamide (27) N-Benzyl-7-chloro-2-methylimidazo[1,2-a]pyridine-3-carboxamide (28) N-Benzyl-6-chloro-2-methylimidazo[1,2-a]pyridine-3-carboxamide (29) N-Benzyl-2,8-dimethylimidazo[1,2-a]pyridine-3-carboxamide (30) N-Benzyl-2,7-dimethylimidazo[1,2-a]pyridine-3-carboxamide (31) N-Benzyl-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide (32) N-Benzyl-2,5-dimethylimidazo[1,2-a]pyridine-3-carboxamide (33) N-Benzyl-6-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxamide (34) N-Benzyl-7-cyano-2-methylimidazo[1,2-a]pyridine-3-carboxamide (35) N-Benzyl-6-cyano-2-methylimidazo[1,2-a]pyridine-3-carboxamide (36) N-Benzyl-2-methyl-7-phenylimidazo[1,2-a]pyridine-3-carboxamide (37) N-Benzyl-2-methyl-6-phenylimidazo[1,2-a]pyridine-3-carboxamide (38) N-Benzyl-8-fluoro-2-methylimidazo[1,2-a]pyridine-3-carboxamide (39) N-Benzyl-2-methyl-8-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide (40) N-Benzyl-8-methoxy-2-methylimidazo[1,2-a]pyridine-3-carboxamide (41) N-Benzyl-8-cyano-2-methylimidazo[1,2-a]pyridine-3-carboxamide (42) N-Benzyl-8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxamide (43) N-Benzyl-2-ethylimidazo[1,2-a]pyridine-3-carboxamide (46) N-Benzyl-2-propylimidazo[1,2-a]pyridine-3-carboxamide (48) N-Benzyl-2-cyclopropylimidazo[1,2-a]pyridine-3-carboxamide (50) N-Benzyl-2-isopropylimidazo[1,2-a]pyridine-3-carboxamide (51) N-Benzyl-2-phenylimidazo[1,2-a]pyridine-3-carboxamide (53) 2-Ethyl-N-(4-(trifluoromethoxy)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (59) 2-Ethyl-7-methyl-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (68) 2-Ethyl-7-methyl-N-(naphthalen-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide (69) 6-Chloro-2-methyl-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (74) 6-Chloro-2-ethyl-N-(4-(piperidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (79) 6-Chloro-2-ethyl-N-(naphthalen-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide (80) 7-Chloro-2-ethyl-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (89) 7-Chloro-2-ethyl-N-(4-(piperidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (90) 7-Chloro-2-ethyl-N-(naphthalen-2-ylmethyl)imidazo[1,2-a]pyridine-3-carboxamide (91) N-(7-Chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)biphenyl-4-carboxamide (142) 2-(Biphenyl-4-yl)-N-(7-chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)acetamide (143) [1,1′-Biphenyl]-4-ylmethyl 6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxylate (161) 4-Phenoxybenzyl 6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxylate (196) 6-Chloro-2-ethyl-N-(4-(pyrrolidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (211) 7-Chloro-2-ethyl-N-(4-(pyrrolidin-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (212) 7-Chloro-N-(4-(5,6-dihydropyridin-1(2H)-yl)benzyl)-2-ethylimidazo[1,2-a]pyridine-3-carboxamide (213) 2-ethyl-6-methyl-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (219) N-(4-(Azepan-1-yl)benzyl)-6-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxamide (221) N-(4-(Azepan-1-yl)benzyl)-7-chloro-2-ethylimidazo[1,2-a]pyridine-3-carboxamide (222) 6-Chloro-2-ethyl-3-((4-(trifluoromethoxy)phenoxy)methyl)imidazo[1,2-a]pyridine (239) N-((6-Chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)methyl)-4-(trifluoromethoxy)aniline (240) N-((6-Chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)methyl)-4-(4-(4-fluorophenyl)piperazin-1-yl)aniline (241) N-((6-Chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)methyl)-4-(4-fluorophenoxy)aniline (242) 5-(6-Chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(trifluoromethoxy)benzyl)-1,2,4-oxadiazole (243) 2-(7-Chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-5-((4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)methyl)-1,3,4-oxadiazole (244) 5-(6-Chloro-2-ethylimidazo[1,2-a]pyridin-3-yl)-3-(4-(4-fluorophenoxy)benzyl)-1,2,4-oxadiazole (245) 6-Chloro-N,2-diethylimidazo[1,2-a]pyridine-3-carboxamide (246) 6-Chloro-2-ethyl-N-isobutylimidazo[1,2-a]pyridine-3-carboxamide (247) 7-Chloro-2-ethyl-N-(4-(4-fluorophenoxy)benzyl)imidazo[1,2-a]pyridine-3-carboxamide (264) 2-Ethyl-6-fluoro-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (313) 2-Ethyl-7-methoxy-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (314) 6-Bromo-2-ethyl-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (315) 2-Ethyl-6-fluoro-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (316) 2-Ethyl-8-fluoro-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (317) 2-Ethyl-8-methoxy-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (318) 8-(Difluoromethoxy)-2-ethyl-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (319) 8-Bromo-2-ethyl-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (320) 2-Ethyl-N-(4-morpholinobenzyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide (321) 2-Ethyl-N-(4-morpholinobenzyl)-7-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide (322) 2-Ethyl-N-(4-morpholinobenzyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide (323) 7-Bromo-2-ethyl-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (324) 2-Ethyl-N-(4-morpholinobenzyl)-7-(pyridin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (325) 2-Ethyl-N-(4-morpholinobenzyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide (326) 2-Ethyl-N-(4-morpholinobenzyl)-8-(pyridin-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (327) 2-Ethyl-7-(4-methylpiperazin-1-yl)-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (328) 2-Ethyl-7-(4-(4-fluorophenyl)piperazin-1-yl)-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (329) 2-Ethyl-7-(4-(4-fluorobenzyl)piperazin-1-yl)-N-(4-morpholinobenzyl)imidazo[1,2-a]pyridine-3-carboxamide (331) |