Pharmacokinetics of S-adenosylmethionine formulations

摘要

Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.

主权项

1. A composition comprising a physiologically effective amount of S-adenosylmethionine (SAMe), wherein non-parenteral administration of said composition to a selected human subject group produces in said selected human subject group an average SAMe plasma area under the curve (average AUC) of at least 600 ng·h/mL per each 100 mg dosage of SAMe ion delivered and an average Cmax of at least 110 ng/mL per each 100 mg dosage of SAMe ion delivered, and wherein said composition is a tablet dosage form comprising a functional coating.