| 摘要 |
<p>A device for detecting the presence of a hazardous target molecule in a sample is provided. It comprises:•a chamber (18,19) for containing the sample;•a substrate (15), located in the chamber (18,19), which is provided with at least one nanopore (17) therethrough;•at least one nanostructure (16), juxtaposed within the nanopore (17) or on a surface of the substrate (15) adjacent thereto, each nanostructure (16) being capable of generating an associated detection window comprising an electromagnetic field by having induced therein localised surface plasmons;•a source of incident electromagnetic radiation (23) for inducing said localised surface plasmons in said nanostructure(s) (16);•at least one means (20,21) for establishing a gradient between the sample and the substrate (15) for driving the target molecule from the sample into the detection window and•a detector (25) for detecting electromagnetic radiation emitted by the target molecule as it passes though the electromagnetic field. Preferably the gradient is an electrophoretic or dielectrophoretic field gradient. The device is especially suitable for detecting trace amounts of noxious substances such as biological agents, toxic chemicals, poisonous gases, narcotics or traces of explosive material or residues.</p> |
