| 发明名称 | Recombinant <i>Novirhabdoviruses </i>and uses thereof | ||
| 摘要 | The invention relates to recombinant novirhabdoviruses having at least one sequence encoding a polypeptide of interest added to their genome. Said recombinant novirhabdoviruses are useful as gene vectors, for producing recombinant proteins, or for producing vaccines for fish or for higher vertebrates. | ||
| 申请公布号 | US8859276(B2) | 申请公布日期 | 2014.10.14 |
| 申请号 | US200712304812 | 申请日期 | 2007.06.15 |
| 申请人 | Institut National de la Recherche Agronomique | 发明人 | Harmache Abdallah;Bremont Michel;Koumans Joseph |
| 分类号 | C12N15/63;C12N15/00;C12N15/09;C12N15/11;C12N15/86;C12N7/00 | 主分类号 | C12N15/63 |
| 代理机构 | Morgan, Lewis & Bockius LLP | 代理人 | Morgan, Lewis & Bockius LLP |
| 主权项 | 1. A recombinant DNA construct consisting of: a) a transcriptional termination/polyadenylation sequence of novirhabdovirus M gene as set forth in the nucleotide sequence of SEQ ID NO: 4; b) a transcription initiation sequence of novirhabdovirus G gene as set forth in the nucleotide sequence of SEQ ID NO: 5; c) a non-transcribed intergenic dinucleotide of a novirhabdovirus preceded by said transcriptional termination/polyadenylation sequence, or followed by said transcription initiation sequence; and d) an open reading frame encoding a protein of interest. | ||
| 地址 | Paris FR | ||