METHOD FOR PRODUCING OPTICAL ACTIVITY α-BROMOBENZOYL ACETIC ESTERS

摘要

PROBLEM TO BE SOLVED: To provide a method for producing optical activity α-bromobenzoyl acetic esters at high enantioselectivity using an asymmetric metal complex catalyst.SOLUTION: Benzoyl acetic esters are reacted with a bromination agent in the presence of an asymmetric nickel complex catalyst prepared from a nickel salt and an optical activity bisoxazoline ligand and synthetic zeolite to obtain optical activity α-bromobenzoyl acetic esters at high enantioselectivity.