| 发明名称 |
STABLE FORMULATIONS OF BOTULINUM TOXIN IN HYDROGELS |
| 摘要 |
The invention includes liquid formulations of botulinum toxin, including hydrogel formulations that are stable to storage in liquid form at standard refrigerator temperatures for at least 1-2 years and to storage at higher temperatures for at least 6 months. The invention also includes methods of treatment using such formulations for various therapeutic and cosmetic purposes. |
| 申请公布号 |
US2014302008(A1) |
申请公布日期 |
2014.10.09 |
| 申请号 |
US201414308136 |
申请日期 |
2014.06.18 |
| 申请人 |
Solstice Neurosciences, LLC |
发明人 |
Moyer Elizabeth;Hirtzer Pamela;Digenis George A.;Malkawi Ahmad H. |
| 分类号 |
A61K38/48;A61K47/42 |
主分类号 |
A61K38/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A stable liquid pharmaceutical botulinum toxin formulation for therapeutic use in humans, comprising a pharmaceutically acceptable buffer capable of providing a buffered pH range between about pH 5 and pH 6;
sodium chloride; a therapeutic concentration of a purified botulinum toxin suitable for use in humans, wherein said purified botulinum toxin has not been dried or lyophilized; and a hydrogel forming material; wherein said formulation is stable as a liquid for at least one year at a temperature between about 0 and 10 degrees centigrade |
| 地址 |
Louisville KY US |
