STABILISATION OF POLYPEPTIDES

摘要

A method for preserving a polypeptide comprising: (a) providing an aqueous solution of (i) the polypeptide, (ii) one or more sugars, and (iii) a compound of formula (I) or a physiologically acceptable salt or ester thereof and/or a compound of formula (II) or a physiologically acceptable salt or ester thereof; and (b) drying the solution to form a composition incorporating the polypeptide.

主权项

1. A method for preserving a polypeptide comprising:
(a) providing an aqueous solution of (i) the polypeptide, (ii) one or more sugars, and (iii) a compound of formula (I) or a physiologically acceptable salt or ester thereofwherein:
R1 represents hydrogen or C1-6 alkyl; and R4 represents hydrogen; or R1 and R4 together with the atoms to which they are attached form a pyrrolidine ring; R2 represents hydrogen, C1-6 alkyl or —(CH2)2-5NHC(O)(CH2)5-15CH3; and R3 represents C1-6 alkyl; and/or a compound of formula (II) or a physiologically acceptable salt or ester thereofwherein:
X represents —S(O)2— or —S+(Rc)—, Ra and Rb independently represent C1-6 alkyl; and Rc represents C1-6 alkyl substituted with a carboxylate anion and with an amine (—NH2) moiety; and (b) drying the solution to form a composition incorporating the polypeptide.