| 发明名称 |
BIOMARKERS FOR CANCERS RESPONSIVE TO MODULATORS OF HEC1 ACTIVITY |
| 摘要 |
Contemplated compositions and methods are drawn to biomarkers and methods related to treatment of neoplastic disease with Hec1 inhibitor. Gene status and/or expression levels of Hec1(HEC), Rb(RB1), and/or p53 (TP53) may be useful as biomarkers for sensitivity to treatment with a Hec1 inhibitor. In addition, Hec 1 inhibitors may show synergistic effects when used in conjunction with cytotoxic drugs. |
| 申请公布号 |
EP2783217(A1) |
申请公布日期 |
2014.10.01 |
| 申请号 |
EP20120851702 |
申请日期 |
2012.11.19 |
| 申请人 |
TAIVEX THERAPEUTICS CORPORATION |
发明人 |
HUANG, YU-LING;LAU, JOHNSON |
| 分类号 |
G01N33/566;A61K31/337;A61K31/4439;A61K31/4745;A61K31/497;A61K31/704;A61K45/06;A61P35/00;C07D277/04;C07D277/82;C12Q1/68;G01N33/50;G01N33/574;G01N33/68 |
主分类号 |
G01N33/566 |
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