| 主权项 |
1. An ECM valve conduit for regenerating an atrioventricular (AV) valve to replace a defective AV valve within a heart of a subject, the AV valve being attached to an annular region of the heart. the defective AV valve and annular region of the heart comprising first cardiovascular tissue, the defective AV valve further comprising a first plurality of valve leaflets, comprising:
a bioabsorbable tubular conduit member comprising sterile, acellular small intestine submucosa (SIS), said SIS comprising less than 4% DNA content and a dry weight bFGF content of at least 140 pg/mg of said SIS, said SIS further exhibiting at least 96% decellurization and a tensile strength of at least 9 N, said ECM conduit member defining a lumen and having an inlet portion and an outlet portion, said inlet portion of said ECM conduit member being configured to attach to an said annular region of said heart of said subject, said outlet portion of said ECM conduit member being configured to attach to papillary muscles within said subject's heart, said ECM conduit member being configured to induce generation of a plurality of regenerated valve leaflets in said ECM conduit member lumen when said ECM conduit member is coupled to said first cardiovascular tissue of said annular region, said plurality of regenerated valve leaflets comprising second cardiovascular tissue, said second cardiovascular tissue and said first cardiovascular tissue being similar, said plurality of regenerated valve leaflets being configured to function in a manner similar to said first valve leaflets of said defective AV valve. |
