| 发明名称 |
MODIFIED ANTIBODY WITH IMPROVED HALF-LIFE |
| 摘要 |
The present invention relates to antibodies, immunoglobulin constructs or immunoglobulin IgG4 fusion proteins whose in vivo half-lives are increased by the combination of (i) a modified IgG4 Fc region or FcRn binding domain thereof and (ii) a modified IgG4 hinge region sequence. |
| 申请公布号 |
ZA201305123(B) |
申请公布日期 |
2014.09.25 |
| 申请号 |
ZA20130005123 |
申请日期 |
2013.07.08 |
| 申请人 |
TEVA PHARMACEUTICALS AUSTRALIA PTY LTD |
发明人 |
WILSON DAVID;TAURA TETSUYA |
| 分类号 |
A61K;C07K;C12N |
主分类号 |
A61K |
| 代理机构 |
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代理人 |
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| 主权项 |
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