发明名称 |
TRANSDERMAL FORMULATIONS OF LAQUINIMOD |
摘要 |
This invention provides a transdermal patch comprising: a) a backing layer; b) a liner; c) optionally, a highly porous membrane; and d) a pharmaceutical composition comprising: (i) optionally, a pressure sensitive adhesive in an amount of up to about 95 wt% of the pharmaceutical composition, (ii) laquinimod in an amount of about 0.1-20 wt% of the pharmaceutical composition, and (iii) optionally, one or more permeation enhancers in a total amount of up to about 70 wt% of the pharmaceutical composition. This invention also provides a method for delivering laquinimod across the skin of a subject and for treating a human subject afflicted with a form of multiple sclerosis comprising administering to the skin of the subject a transdermal patch as described herein. This invention further provides a transdermal patch as described herein for use in treating a human subject afflicted with a form of multiple sclerosis. |
申请公布号 |
CA2900977(A1) |
申请公布日期 |
2014.09.25 |
申请号 |
CA20142900977 |
申请日期 |
2014.03.13 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
STEFAN, RALPH;MIKA, HANS-JUERGEN;PRIES, TANJA;SCHENK, DIRK;PROHL, SABINE |
分类号 |
A61K9/70;A61K31/4704 |
主分类号 |
A61K9/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|