发明名称 |
EXO OLEFIN-CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF |
摘要 |
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and, more particularly, to a compound represented by structural formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity. |
申请公布号 |
WO2014152263(A1) |
申请公布日期 |
2014.09.25 |
申请号 |
WO2014US27136 |
申请日期 |
2014.03.14 |
申请人 |
KARYOPHARM THERAPEUTICS INC.;KATOLIEKE UNIVERSITEIT LEUVEN |
发明人 |
SANDANAYAKA, VINCENT, P.;SHECHTER, SHARON;DAELEMANS, DIRK;LEEN, VOLKER;DEHAEN, WIM, ALFONS;SHACHAM, SHARON |
分类号 |
C07D401/06;A61K31/41;A61K31/4196;A61K31/4245;A61K31/4402;A61K31/506;C07D249/08;C07D257/04;C07D413/06 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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