CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES.

摘要

The invention relates to compounds that are characterized by possessing at least four cycles (A-C and phenylene ring). Such compounds modulate the glucagon-like peptide 1 (GLP-1) receptor and have a therapeutic use that includes diseases such as diabetes, obesity and excessive appetite. The compounds act as modulators or potentiators of the GLP-1 receptor, or act with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide. Claimed are compounds of the fol lowing genera structure (" ﹋ "1 represents undefined stereochemistry) : [Formula I] where the variables A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p and q are as defined in the claims.