Methods for Modulating Bacterial Virulence and Related Compounds

摘要

The present invention relates to compounds and methods for the treatment of bacterial infections. The compounds and methods involve the disruption of the QseC signaling pathway which modulates the virulence of some bacteria. This methodology for treatment of bacterial infections reduces evolutionary pressure to develop resistance because the bacteria are not killed in the process.

主权项

1. A method of treating or preventing bacterial infection in a subject, comprising administering to the subject an effective amount of the following molecular formula:wherein:
R1 and R2 are each independently hydrogen, cyano, nitro, halo, —C(O)OCH2CH3, C1-C8-alkyl, C1-C8-aryl, or a substituted version of those groups; R3 is hydrogen or C1-C6-alkyl; or R4 is C1-C10-aryl, C1-C6-alkyl, C6-C12-cycloalkyl, or a substituted version of those groups or a pharmaceutically acceptable salt, thereof.