| 发明名称 | Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3 | ||
| 摘要 | The invention provides methods and compositions comprising anti-EphA3 antibodies for the treatment of myeloproliferative disorders. | ||
| 申请公布号 | US8834870(B2) | 申请公布日期 | 2014.09.16 |
| 申请号 | US201012718768 | 申请日期 | 2010.03.05 |
| 申请人 | Kalobios Pharmaceuticals, Inc. | 发明人 | Bebbington Christopher R.;Yarranton Geoffrey T.;Palath Varghese |
| 分类号 | A61K39/395 | 主分类号 | A61K39/395 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A method of killing myeloproliferative disorder cells that express EphA3 on the cell surface, the method comprising contacting the cells with an anti-EphA3 antibody, wherein the anti-EphA3 antibody (i) activates EphA3 and (ii) induces antibody-dependent cell-mediated cytotoxicity (ADCC). | ||
| 地址 | South San Francisco CA US | ||