| 主权项 |
1. A compound of Formula I:in which:X1 is —CF3, —CF2CF3 or —CHF2;R1 is a group of Formula (a), (b) or (c):where R4 is (C1-3)-n-alkyl or (C3-4)cycloalkylmethyl and R5 is hydrogen, (C1-3)alkyl or (C3-7)cycloalkyl;R2 is a group of Formula (d), (e) or (f):where X2 and X3 are independently fluoro, iodo, bromo or chloro; andR3 is one to three substituents selected from hydrogen, C1-6alkoxy, C3-6cycloalkoxy, fluoro, chloro, bromo, trifluoromethyl, trifluoromethoxy, heteroaryl or heterocyclyl, wherein the heteroaryl and heterocyclyl may be further substituted with 2,2,2-trifluoroethyl, (C1-6)alkyl, or (C3-6)cycloalkyl; and the pharmaceutically acceptable salts thereof. |
