Modulators of MYC, methods of using the same, and methods of identifying agents that modulate MYC

摘要

Disclosed herein are methods of modulation of the viability of a cell. Further disclosed herein are methods of modulating an immune response. Further disclosed herein are methods of identifying agents capable of modulation of the viability of a cell or an immune response. Further disclosed herein are agents and compositions capable of modulation of the viability of a cell or an immune response.

主权项

1. A method, comprising:
(a) providing an antigenic moiety and a fusion peptide to one or more immune cells in vitro, wherein the fusion peptide comprises:
(i) a transporter peptide sequence;(ii) a MYC polypeptide sequence; and, optionally,(iii) one or more molecules that link the transporter peptide sequence and the MYC polypeptide sequence; and (b) culturing the one or more immune cells under conditions sufficient for the fusion peptide to increase one or more of activation, survival, or proliferation of the one or more immune cells, as compared with corresponding immune cells not exposed to the fusion peptide.