发明名称 |
Metodo para sintetizar n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil) fenil)]acetamida y mesilato monohidrato cristalino del mismo; composicion farmaceutica que lo contiene; combinacion farmaceutica; uso en el tratamiento y/o profilaxis de una infeccion por virus herpes simplex. |
摘要 |
The present invention relates to an improved and shortened synthesis of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions. |
申请公布号 |
CL2014000149(A1) |
申请公布日期 |
2014.09.05 |
申请号 |
CL20140000149 |
申请日期 |
2014.01.20 |
申请人 |
AICURIS GMBH & CO. KG |
发明人 |
REHSE JOACHIM;SCHWAB WILFRIED;BIRKMANN ALEXANDER;VOGTLI KURT;HAAG DIETER;LENDER ANDREAS;KEIL BIRGIT;GRUNENBERG ALFONS |
分类号 |
C07D417/12;A61K31/427;A61K31/4402;A61P31/22 |
主分类号 |
C07D417/12 |
代理机构 |
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代理人 |
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