Process for Preparing 5-biphenyl-4-amino-2-methyl Pentanoic Acid

摘要

The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof,;;wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.

主权项

1. A compound selected from the group consisting of
a) a compound according to formula (2), or tautomer, or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group, b) a compound according to formula (13), or tautomer, or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group, c) a compound according to formula (15), or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group, d) a compound according to formula (16), or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group, e) a compound according to formula (20), or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group, R10 is a group which can be saponified and/or decarboxylated and R11 is hydrogen or methyl. f) a compound according to formula (21), or tautomer, or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group, and g) a compound according to formula (22), or tautomer, or salt thereof, wherein R1 is hydrogen or a nitrogen protecting group.