发明名称 |
TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM |
摘要 |
A process of production of trazodone or trazodone hydrochloride that comprises: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature of at least 40° C. for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride. |
申请公布号 |
EP2178850(B1) |
申请公布日期 |
2014.09.03 |
申请号 |
EP20080775309 |
申请日期 |
2008.07.23 |
申请人 |
AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. |
发明人 |
MARCHETTI, MARCELLO;IACOANGELI, TOMMASO;CIOTTOLI, GIOVANNI BATTISTA;BIONDI, GIUSEPPE |
分类号 |
C07D249/18;A61K31/4196;A61P25/22;A61P25/24 |
主分类号 |
C07D249/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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