Dosage regimens for HCV combination therapy

摘要

The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin and particular regimens for administering this combination. Compound (1) is a selective and potent inhibitor of the HCV NS3 serine protease. The present invention also relates to methods of using such therapeutic combinations for treating HCV infection or alleviating one or more symptoms thereof in a patient.

主权项

1. A method of treating hepatitis C viral (HCV) infection in a patient comprising administering to the patient a therapeutic combination comprising:
(a) Compound (1) or a pharmaceutically acceptable salt thereof: (b) an interferon alpha; and (c) ribavirin, wherein the first dose of Compound (1), or a pharmaceutically acceptable salt thereof, that is administered to the patient is double in quantity by weight to the subsequent doses thereof and wherein Compound (1), or a pharmaceutically acceptable salt thereof, is administered at a dosage of about 240 mg to about 480 mg in the first dose, and at a dosage of about 120 mg to about 240 mg in subsequent doses.