发明名称 |
Inhibiteurs de l'enzyme activant nedd8 |
摘要 |
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer. |
申请公布号 |
MA35439(B1) |
申请公布日期 |
2014.09.01 |
申请号 |
MA20140036826 |
申请日期 |
2014.03.13 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC |
发明人 |
MCCARRON ASHLEY, SUE;SELLS TODD, B;STIRLING MATTHEW;STROUD STEPHEN, G |
分类号 |
C07D487/04;A61K31/505;A61K31/519;A61P35/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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