发明名称 |
NOVEL HETEROARENE ANTHRACENEDIONE-BASED G-QUADRUPLEX LIGANDS INHIBITING TUMOUR CELL GROWTH |
摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to linear heterocyclic anthracenedione derivatives containing guanidino(alkylamino) groups in positions 2, 4 and 11 and having the formula:as well as pharmacologically acceptable salts, where X independently denotes a heteroatom selected from O, S or an NH group which forms a five-member heteroarene condensed with an anthracenedione nucleus at bonds 2-3; n independently denotes a number from 2 to 4, which is equal to the number of spacer CHgroups which link amino groups in peri-positions of heteroarene anthracenedione with nitrogen atoms of guanidine group residues located in side chains; m independently denotes a number from 2 to 4, which is equal to the number of spacer CHgroups which link the nitrogen atom of a carboxamide group located at position 2 of the heterocyclic nucleus of heteroarene anthracenedione with the nitrogen atom of the guanidine group residue located in the side chain.EFFECT: obtaining novel compounds which can be used in medicine for therapy of cancerous diseases.2 tbl, 2 dwg, 8 ex |
申请公布号 |
RU2527459(C1) |
申请公布日期 |
2014.08.27 |
申请号 |
RU20130113321 |
申请日期 |
2013.03.27 |
申请人 |
FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT PO IZYSKANIJU NOVYKH ANTIBIOTIKOV IM. G.F. GAUZE" ROSSIJSKOJAKADEMII MEDITSINSKIKH NAUK (FGBU "NIINA" RAMN) |
发明人 |
SHCHEKOTIKHIN ANDREJ EGOROVICH;TIKHOMIROV ALEKSANDR SERGEEVICH;IL'INSKIJ NIKOLAJ SERGEEVICH;KALJUZHNYJ DMITRIJ NIKOLAEVICH;SHCHELKINA ANNA KIRILLOVNA;BORISOVA OL'GA FILIPPOVNA;LIVSHITS MIKHAIL ARONOVICH;TSVETKOV VLADIMIR BORISOVICH;BYCHKOVA ELENA NIKOLAEVNA;MALJUTINA NATAL'JA MIKHAJLOVNA;DEZHENKOVA LJUBOV' GEORGIEVNA;SHTIL' ALEKSANDR AL'BERTOVICH;PREOBRAZHENSKAJA MARIJA NIKOLAEVNA |
分类号 |
C07D307/77;A61K31/343;A61K31/381;A61P35/00;C07D333/50 |
主分类号 |
C07D307/77 |
代理机构 |
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