CORTICAL BONE SCAFFOLD FOR GUIDED OSTEON REGENERATION IN LOAD-BEARING ORTHOPAEDIC APPLICATIONS

摘要

Described is an artificial bone scaffold with an architecture resembling cortical bone, including microchannel-like structures resembling osteons. The scaffold enhances the ability of osteoblasts to secrete organized collagen and mineralize extracellular matrix within the osteon-like channels, thus promoting scaffold strength.

主权项

1. A method of forming a scaffold for the repair of load-bearing bone damage comprising:
obtaining a mold having an interior space that is complementary to the bone repair site; coupling wires to the mold, such that the wires extend through an interior space of the mold placing a fluid composition of hydroxyapatite and β-tricalcium phosphate into the interior space of the mold; wherein the fluid composition surrounds at least a portion of the wires; removing the wires from the mold after the fluid composition hardens.