COMPOUNDS FOR IMPROVED VIRAL TRANSDUCTION

摘要

The present invention provides methods and compositions for improving the efficacy of viral transduction of cells. More particularly, the present invention provides methods and materials useful for safely and reliably improving the efficiency of methods for transducing cells, such as human hematopoietic stem cells (HSC), with viruses and/or viral vectors. The compositions and methods are useful for therapeutic indications amenable to treatment with hematopoietic stem cell gene therapies.

主权项

1. A method for increasing the transduction efficiency of cells cultured with a retrovirus comprising: culturing the cells and the retrovirus in a culture medium that comprises a compound that increases prostaglandin EP receptor signaling.