发明名称 | Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response | ||
摘要 | The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant or an antibody directed thereto. | ||
申请公布号 | US8808699(B2) | 申请公布日期 | 2014.08.19 |
申请号 | US201113639465 | 申请日期 | 2011.04.05 |
申请人 | The University of Chicago | 发明人 | Schneewind Olaf;Cheng Alice;Missiakas Dominique M.;Kim Hwan Keun |
分类号 | A61K39/085;A61K39/40 | 主分类号 | A61K39/085 |
代理机构 | Fulbright & Jaworski LLP | 代理人 | Fulbright & Jaworski LLP |
主权项 | 1. A method for enhancing an immune response against a Staphylococcus aureus bacterium in a subject comprising: (a) providing to the subject a composition comprising an isolated antibody that specifically binds to a nontoxigenic Staphylococcus aureus Protein A (SpA) epitope SpAKKAA; and (b) providing to the subject a staphylococcal antigen, wherein the antigen is selected from the group consisting of: FnBpA, FnBpB, LukD, LukE, LukF, SasA, SasD, SasG, SasI, SasK, SpA variant, Eap, Ebh, Emp, EsaB, EsaC, EsxA, EsxB, SdrC, SdrD, SdrE, IsdA, IsdB, ClfA, ClfB, Coa, Hla, IsdC, SasF, vWbp, and vWh; wherein the antibody enhances an immune response against a Staphylococcus aureus antigen. | ||
地址 | Chicago IL US |