| 发明名称 | Genetically modified bacterium of the species <i>Listeria monocytogenes</i> | ||
| 摘要 | The present invention relates to a genetically modified bacterium of the species Listeria monocytogenes, wherein the genomic locus of the transcriptional factor PrfA has been deleted, characterized in that it comprises on genomic level an artificial sequence that acts as internal amplification control, the use of this bacterium as well as a method for detecting and determining qualitatively and/or quantitatively the occurrence of wild type Listeria monocytogenes in a sample suspected to be contaminated with said micro-organism and a kit. | ||
| 申请公布号 | US8808683(B2) | 申请公布日期 | 2014.08.19 |
| 申请号 | US201113701142 | 申请日期 | 2011.04.29 |
| 申请人 | Merck Patent GmbH | 发明人 | Rossmanith Peter;Fruehwirth Karin;Wagner Martin;Fuchs Sabine |
| 分类号 | A61K39/02;A01N63/00;C07H21/02 | 主分类号 | A61K39/02 |
| 代理机构 | Millen, White, Zelano & Branigan, P.C. | 代理人 | Millen, White, Zelano & Branigan, P.C. |
| 主权项 | 1. A genetically modified bacterium of the species Listeria monocytogenes comprising a deletion of the genomic locus of the transcriptional factor PrfA and further comprising, at the genomic level, an artificial sequence comprising the nucleic acid sequence of SEQ ID NO: 1 that acts as internal amplification control (IAC). | ||
| 地址 | Darmstadt DE | ||