| 主权项 |
1. A compound of Formula I:wherein:
X1, X2, X3, and X4 are independently —N— or —CR4— wherein R4 is hydrogen, alkyl, or halo with the proviso that not more than three of X1, X2, X3 and X4 are —N—; R1 is hydrogen, alkyl, halo, carboxy or aminocarbonyl; R2 is hydrogen, alkyl, or halo; R3 is dicarboxyalkylaminocarbonylalkyl or dicarboxyalkylaminocarbonyl-cycloalkyl; Rx is hydrogen, alkyl, alkylthio, halo, hydroxy, hydroxyalkyl, alkoxy, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, or nitro; Ry is hydrogen, alkyl, or halo; Rx is hydrogen, alkyl, haloalkyl, cycloalkyl, alkylthio, halo, hydroxy, hydroxyalkyl, nitro, cyano, alkoxy, alkoxyalkyl, alkoxyalkyloxy, hydroxyalkyloxy, aminoalkyloxy, carboxyalkyloxy, aminocarbonylalkyloxy, haloalkoxy, carboxy, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, cyanoalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonyl, heteroarylsulfonyl, carbamimidoyl, hydroxy-carbamimidoyl, alkoxycarbamimidoyl, alkylsulfonylamino, alkylsulfonylaminoalkyl, alkoxysulfonylamino, alkoxysulfonylaminoalkyl, heterocycloalkylalkylaminocarbonyl, hydroxyalkoxyalkylaminocarbonyl, heterocycloalkylcarbonyl, heterocycloalkylcarbonyl-alkyl, heterocycloalkyl, heterocycloalkylalkyl, oxoheterocycloalkyl, oxoheterocycloalkyl-alkyl, heteroaryl, heteroaralkyl, ureido, alkylureido, dialkylureido, ureidoalkyl, alkylureidoalkyl, dialkylureidoalkyl, thioureido, thioureidoalkyl, —COR12 (where R12 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, or aminoalkyl), -(alkylene)-COR12 (where R12 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, or aminoalkyl), —CONR14R15 (where R14 is hydrogen or alkyl and R15 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl), -(alkylene)-CONR16R17 (where R16 is hydrogen, alkyl or hydroxyalkyl and R17 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl), —NR18R19 (where R18 is hydrogen or alkyl and R19 is hydrogen, alkyl, acyl, aryl, aralkyl, heteroaryl, or heteroaralkyl), -(alkylene)-NR20R21 (where R20 is hydrogen, alkyl, or hydroxyalkyl and R21 is hydrogen, alkyl, acyl, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl), —SO2NR22R23 (where R22 is hydrogen or alkyl and R23 is hydrogen, alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, or R22 and R23 together with the nitrogen atom to which they are attached form heterocycloamino), -(alkylene)-SO2NR24R25 (where R24 is hydrogen or alkyl and R25 is hydrogen, alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl or R24 and R25 together with the nitrogen atom to which they are attached form heterocycloamino), —NR26SO2NR27R28 (where R26 and R27 are independently hydrogen or alkyl, and R28 is hydrogen, alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, or R27 and R28 together with the nitrogen atom to which they are attached form heterocycloamino), -(alkylene)-NR29SO2NR30R31 (where R29 and R30 are independently hydrogen or alkyl, and R31 is hydrogen, alkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl or R30 and R31 together with the nitrogen atom to which they are attached form heterocycloamino), —CONH-(alkylene)-NR32R33 where R32 is hydrogen or alkyl and R33 is alkyl), or aralkyl; and R13 is hydrogen, hydroxy, (C1-10)alkoxy, —C(O)R35 where R35 is alkyl, aryl, haloalkyl, or cyanoalkyl, or —C(O)OR36 where R36 is alkyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyl, aryl, or haloalkyl; ora zwitterion thereof; or a pharmaceutically acceptable salt thereof. |
