Use of scintillator-based nanoparticles for in vivo control of light-sensitive bioactive molecules

摘要

The method for remote, non-invasive in vivo control of the activation of light-sensitive bioactive molecules for the purpose of research or therapy is based on delivering to the required site of the body of nanoparticles along with said light-sensitive bioactive molecules. Nanoparticles' core is made from scintillator material that absorbs X-ray and in response emits visible light; they have biocompatible protective coating and surface targeting agents enabling accumulation at the required site(s) within the body. Irradiation of the site with the highly penetrable X-rays causes nanoparticles to emit visible light which will activate light-sensitive bioactive molecule(s) within this site inducing sought therapeutic effect.

主权项

1. The method for non-invasive in vivo control of light-sensitive bioactive molecules with the purpose of research and therapy, comprising:
a light-sensitive bioactive molecule; a biocompatible nanoparticle;
wherein a core of said nanoparticle consists of scintillator material that absorbs highly penetrable X-ray and in response emits visible light;wherein scintillator material core part of said nanoparticle is covered with biocompatible protective coating;wherein the coating of said nanoparticle bears conjugated antibodies against surface proteins of target cells; said light-sensitive bioactive molecule being delivered to target cells inside the body by direct injection into specific site, via bloodstream or using gene transfer technologies; said nanoparticle being delivered to target cells inside the body by direct injection into specific site or via bloodstream to be simultaneously present with light-sensitive bioactive molecule around the target cells;