Compounds, compositions and methods comprising oxadiazole derivatives

摘要

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-IV) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

主权项

1. A pharmaceutical composition comprising from about 0.01 mg/kg/day to about 100 mg/kg/day of a compound of formula A:or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carrier.