发明名称 |
B-CELL REDUCTION USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES |
摘要 |
<p>The present disclosure generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the disclosure provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the disclosure provides humanized CD37-specific binding molecules.</p> |
申请公布号 |
SI1912675(T1) |
申请公布日期 |
2014.07.31 |
申请号 |
SI20060031765T |
申请日期 |
2006.07.25 |
申请人 |
EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC |
发明人 |
GROSMAIRE LAURA SUE;HAYDEN-LEDBETTER MARTHA SUSAN;LEDBETTER JEFFREY A.;THOMPSON PETER ARMSTRONG;SIMON SANDY ALEXANDER;BRADY WILLIAM |
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