发明名称 |
METHOD AND COMPOSITION TO EVALUATE CYTOCHROME P450 2D6 ISOENZYME ACTIVITY USING A BREATH TEST |
摘要 |
The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by a the subject upon intravenous or oral administration of a 13C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound. |
申请公布号 |
CA2606136(C) |
申请公布日期 |
2014.07.29 |
申请号 |
CA20062606136 |
申请日期 |
2006.04.14 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD.;CAMBRIDGE ISOTOPE LABORATORIES, INC. |
发明人 |
MODAK, ANIL S.;IRIE, YASUO;KUROGI, YASUHISA |
分类号 |
A61K51/00;C12N9/02;C12Q1/00;C12Q1/26;G01N33/50 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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