METHODS AND COMPOSITIONS FOR DIAGNOSIS OF ALZHEIMER'S DISEASE

摘要

The invention provides a method of diagnosing Alzheimer's disease (AD) in a subject by determining the level of expression of one or more miRNAs molecules associated with AD, as well as various nucleic acid molecules relating thereto or derived thereof.

主权项

1. A method of treating Alzheimer's disease (AD) in a subject in need thereof, said method comprising:
(a) diagnosing Alzheimer's disease (AD) in a subject, the method comprising:
(i) obtaining a biological sample from a subject;(ii) determining an expression profile in said sample of a plurality of nucleic acid sequences comprising SEQ ID NOS: 1-67; fragments thereof or sequences having at least about 80% identity thereto;(iii) comparing said expression profile to a reference expression profile whereby a difference in the level of expression profile in at least one or more nucleic acid sequence in said biological sample compared to said reference expression profile is diagnostic for AD; and (b) administering an AD treatment to said patient, wherein said treatment is selected according to said AD diagnosis.