| 主权项 |
1. A compound selected from the group consisting of:
a. anti-LPA agent, which agent specifically binds to LPA under physiological conditions and comprises a peptide amino acid sequence selected from the group consisting of SEQ ID NOs: 162, 163, 164, 165, 166, 167, 168, 169, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, and 189, optionally wherein said anti-LPA agent is selected from the group consisting of an antibody, an antibody derivative, and a non-antibody-derived moiety, wherein the antibody may be a full-length antibody or an antibody fragment, optionally wherein said anti-LPA agent is conjugated to a moiety selected from the group consisting of a polymer, a radionuclide, a chemotherapeutic agent, and a detection agent; b. an isolated nucleic acid molecule that encodes an immunoglobulin heavy chain variable domain that comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188 and 189, optionally wherein said isolated nucleic acid molecule encodes a fragment of an immunoglobulin heavy chain or a full length immunoglobulin heavy chain; c an isolated nucleic acid molecule that encodes an immunoglobulin light chain variable domain that comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 162, 163, 164, 165, 166, 167, 168 and 169, optionally wherein said isolated nucleic acid molecule encodes a fragment of an immunoglobulin light chain or a full length immunoglobulin light chain; and d isolated polypeptide, which polypeptide specifically binds LPA in a physiological context and comprises an amino acid sequence that has a sequence identity of at least 50 percent with a peptide amino acid sequence selected from the group consisting of SEQ ID NO: 162, 163, 164, 165, 166, 167, 168, 169, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188 and 189, optionally wherein the isolated polypeptide is selected from the group consisting of a fragment of a variable domain of an animal immunoglobulin heavy chain, a full length variable domain of an animal immunoglobulin heavy chain, and a full length animal immunoglobulin heavy chain, a fragment of a variable domain of an animal immunoglobulin light chain, a full length variable domain of an animal immunoglobulin light chain and a full length animal immunoglobulin light chain. |
