ANTIBODY-LINKER-DRUG CONJUGATES, PROCESS FOR PREPARING THE SAME AND ANTI-CANCER AGENTS COMPRISING THE SAME

摘要

The present invention relates to an antibody-linker-drug conjugate having an excellent anti-cancer activity, a preparation method thereof, and an anti-cancer agent composition containing the same as an active ingredient. In particular, in the antibody-linker-drug conjugate, the antibody and the cytotoxic drug are conjugated by the catalyst-decomposition type peptide linker, which can be directly bound to a lysine residue of the antibody.