发明名称 |
Compounds that Suppress Cancer Cells and Exhibit Antitumor Activity |
摘要 |
The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitro and antitumor response in vivo. |
申请公布号 |
US2014194468(A1) |
申请公布日期 |
2014.07.10 |
申请号 |
US201314076247 |
申请日期 |
2013.11.10 |
申请人 |
The Governing Council of the University of Toronto ;University of Central Florida Research Foundation, Inc. |
发明人 |
Turkson James;Gunning Patrick |
分类号 |
A61K31/451;A61K31/196 |
主分类号 |
A61K31/451 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Toronto CA |