| 主权项 |
1. A compound having formula (II) or a pharmaceutically acceptable salt form or a stereoisomer thereof, wherein: RA is selected from the group consisting of —N(H)C(O)R8, —O(Ra),—N(Rb)S(O)2Ra, —N(Rb)alkylN(Rb)S(O)2Ra, —N(Rb)alkylN(Rb)C(O)ORa, and -alkylS(O)2Ra; R1 is alkyl; R2 is alkyl; R3 is arylalkyl, wherein the aryl moiety of the arylalkyl is independently substituted with R3a; R3a is heteroaryl selected from the group consisting of thiazolyl, and pyridyl, wherein each R3a is substituted with 0 or 1 substituents independently selected from the group consisting of alkyl and alkoxy; R4 is H and R5 is OR16, or R5 is H and R4 is OR16, or R4 and R5 are —OR16; R16 is hydrogen or R15; R6 is arylalkyl, wherein the aryl moiety of the arylalkyl is independently substituted with 0 or 1 substituents independently selected from the group consisting of R6a; R6a is pyridyl; R7 is —N(Rb)C(O)ORa, alkyl or tetrahydrofuranyl, wherein the alkyl is independently substituted with 0 or 1 substituents independently selected from the group consisting of —ORa, —OC(O)Ra, —SRa, —SORa, —SO2Ra, —N(Ra)C(O)NRaRb, —C(O)NRaRb, —C(O)ORa and R7a; R7a is heteroaryl selected from the group consisting of thiazolyl and pyridyl; R8 is —ORa, —N(Rb)C(O)ORa, -alkylORa, -alkylOC(O)Ra, or —O-alkylC(O)Ra; R15 is —P(O)(OH)2, or -alkyl-O—P(O)(OH)2; Ra and Rb at each occurrence are independently selected from the group consisting of hydrogen, alkyl, aryl and pyridyl, wherein each Ra and Rb, at each occurrence, is independently substituted with 0 or 1 substituent independently selected from the group consisting of alkyl and Rc; and R1 is aryl or pyridyl. |
