Targeted delivery of siRNA

摘要

The present invention provides a method of delivering RNA interference molecules to a cell or a cell in a subject, which comprises contacting the cell with a protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a protein, the protein comprising (1) a targeting moiety, which will specifically bind to a site on a target cell, and (2) a binding moiety linked thereto, which will bind to the double stranded RNA, wherein the double stranded RNA segment is delivered to a cell and effects RNA interference of the target RNA in the cell.

主权项

1. A composition comprising a targeting moiety associated with a binding moiety, wherein a double stranded RNA segment is associated with the binding moiety, wherein the targeting moiety is an antibody or antigen binding fragment thereof which binds to CD7, and the binding moiety is an oligo-9-peptide (9R), wherein the oligo-9-peptide comprises 9 consecutive arginines.