Anti-RSV immunogens and methods of immunization

摘要

Immunogenic polypeptides corresponding to one or more RSV G glycoproteins, or analogs thereof, are provided as components of vaccines. The inventive compositions are useful as both a prophylactic and therapeutic for the prevention and treatment of RSV infections and associated pulmonary or other diseases. The inventive immunogens include regions of the RSV G protein, specifically, amino acid residues 164-176 of RSV G A2 protein or analogs thereof. This inventive immunogen is operable alone or in combination with other polypeptides such as the RSV G protein amino acid residues 155-206, or other vaccines such as live RSV vaccines, or inactivated RSV vaccines or immunogenic analogs thereof.

主权项

1. A respiratory syncytial virus vaccine comprising an isolated immunogen that elicits a protective immune response that protects against an RSV vaccine enhanced RSV immune response said immunogen consisting of an amino acid sequence, said amino acid sequence consisting of the amino acids of:
(i) amino acid position 163 to amino acid position 190 of SEQ ID NO: 8, amino acid position 163 to amino acid position 190 of SEQ ID NO. 7, or amino acid position 163 to amino acid position 190 of SEQ ID NO. 1; (ii) amino acid position 155 to amino acid position 206 of SEQ ID NO: 7, amino acid position 155 to amino acid position 206 of SEQ ID NO: 1, or amino acid position 155 to amino acid position 206 of SEQ ID NO: 8; or a combination thereof.