| 摘要 |
PROBLEM TO BE SOLVED: To provide stabilized IgG4 antibodies reduced in the ability to subject to Fab arm exchange, a method for producing the antibodies, and an application of the antibodies as a medicament.SOLUTION: A stabilized IgG4 antibody for use as a medicament, comprising a heavy chain and a light chain, where the heavy chain comprises a human IgG4 constant region having a substitution of the Arg residue at position 409, the Phe residue at position 405 or the Lys residue at position 370, where the antibody optionally comprises one or more further substitutions, deletions and/or insertions, with the proviso that if the antibody has a residue selected from the group consisting of: Lys, Ala, Thr, Met and Leu at the position corresponding to 409, then the antibody does not comprise a Cys-Pro-Pro-Cys sequence in the hinge region. |
