主权项 |
1. Fulling device for use in tissue engineering of a biological joint replacement to shape and/or differentiate a joint replacement which comprises at least one layer of a joint replacement, comprising a cartilage layer, carrying layer and connective layer between the carrying layer and the cartilage layer, the fulling device comprising:
two fulling bowls which form a fulling gap between them, in which there is a joint replacement and wherein the fulling bowls cover at least part of the surface of the joint replacement, and the shape and curvature of the fulling bowls, including a joint replacement which is mounted on them, at least nearly correspond to the surface of the fulled joint replacement, a flushing device which introduces at least one joint replacement production substance into the fulling gap between the fulling bowls, a fulling point or in hinge joints, a fulling line which form a pressure center and/or minimum distance between the fulling bowls, and which are recurrently moved/fulled with a fulling motion by at least one fulling bowl nearly across the entire surface of the joint replacement, a fulling perform device, comprising: a. at least one fulling motion device which acts on at least one fulling bowl and moves the fulling point or the fulling line, and thereby produces a fulling motion progression between the fulling bowls, b. at least one fulling intensity device to adjust and control a fulling depth and/or fulling pressure from one of the fulling bowls against the other one, wherein the fulling depth corresponds to the reduction of the distance between the fulling bowls and the fulling pressure corresponds to the pressure force of one of the fulling bowls against the other one, and at least one control device to control at least one of the devices comprising the fulling perform device, the fulling motion device, the fulling intensity device and the flushing device. |