| 发明名称 | Topical administrations of antisense compounds to VLA-4 for the treatment of respiratory conditions | ||
| 摘要 | A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 μg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4. | ||
| 申请公布号 | US8765700(B2) | 申请公布日期 | 2014.07.01 |
| 申请号 | US200511666001 | 申请日期 | 2005.10.20 |
| 申请人 | Antisense Therapeutics Ltd. | 发明人 | Tachas George;Karras James G.;Gregory Susan;Crosby Jeffrey R.;Dobie Kenneth W.;Bennett Frank C. |
| 分类号 | C12N15/11 | 主分类号 | C12N15/11 |
| 代理机构 | Quine Intellectual Property Law Group P.C. | 代理人 | Quine Intellectual Property Law Group P.C. |
| 主权项 | 1. A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus comprising topically administering to the respiratory system or airway of the animal an antisense compound targeted to a nucleic acid molecule encoding integrin α4, wherein the antisense compound is administered at a daily dosage level of from 0.01 to 100 μg per kg body weight of the animal. | ||
| 地址 | AU | ||