Microbial engineering for the production of fatty acids and fatty acid derivatives

摘要

Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.

主权项

1. An isolated oleaginous cell, comprising
a recombinant stearoyl-CoA desaturase (SCD) gene that increases expression of SCD, and/or at least one additional copy of a SCD gene, relative to an unmodified cell of the same type, that increases expression of SCD, and a genetic modification that decreases expression of delta-12 desaturase.