发明名称 |
Polypeptide constructs and uses thereof |
摘要 |
The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen. |
申请公布号 |
IL232247(D0) |
申请公布日期 |
2014.06.30 |
申请号 |
IL20140232247 |
申请日期 |
2014.04.24 |
申请人 |
TEVA PHARMACEUTICALS AUSTRALIA PTY LTD;WILSON JR DAVID S;POGUE SARAH L;MIKESELL GLEN E;TAURA TETSUYA;KORVER WOUTER;DOYLE ANTHONY G;CLARKE ADAM;POLLARD MATTHEW;TRAN STEPHEN;LIN JACK TZU-CHIAO |
发明人 |
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分类号 |
C07K |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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