METHODS FOR IDENTIFYING INFLAMMATORY BOWEL DISEASE PATIENTS WITH DYSPLASIA OR CANCER

摘要

The present invention provides methods for identifying IBD patients with dysplasia or cancer. In particular embodiments, the methods of the invention may comprise determining the presence or level of at least one or a panel of miRNAs in a sample obtained from an IBD patient to establish a miRNA expression profile, and comparing the miRNA expression profile with one or more pre-established model miRNA expression profiles. The present invention further provides methods for monitoring the efficacy of treatment of IBD patients with dysplasia or cancer.

主权项

1. A method for identifying an inflammatory bowel disease (IBD) patient with dysplasia or cancer, the method comprising:
(a) determining the presence or level of at least one or a plurality of miRNAs in a sample from the patient to establish a miRNA expression profile; (b) comparing the miRNA expression profile to one or more pre-established model miRNA expression profiles from a control and/or reference standard; and (c) identifying dysplasia or cancer in the IBD patient based upon the comparison in step (b).