| 摘要 |
<p>A method for producing a compound represented by formula (2) or a salt thereof, characterized in that a compound represented by formula (1) or a salt thereof is reacted with 2,2-dialkoxypropane or isopropenyl alkyl ether in the presence of (A) an acid selected from the group consisting of p-toluenesulfonic acid, pyridinium-p-toluenesulfonate, hydrobromic acid, and pyridine hydrobromide, and/or (B) a base selected from the group consisting of pyridine and N,N-dimethylaniline, and (C) water. This production method is suited to the industrial production of a synthetic intermediate of a 1,2-dihydroquinoline derivative having glucocorticoid receptor-binding activity.</p> |
