发明名称 Perylenequinone derivatives and uses thereof
摘要 The present invention relates to compounds which are perylenequinone derivatives, their stereoisomers and atropisomers. These compounds can be particularly useful as photosensitizers or sononsensitizers in photodynamic or sonodynamic therapy. The invention also relates to various methods for using these compounds in photodynamic and/or sonodynamic therapy. The compounds also are useful as therapeutic agents for treating various hyperproliferative disorders.
申请公布号 US8758725(B2) 申请公布日期 2014.06.24
申请号 US201313792456 申请日期 2013.03.11
申请人 Quest Pharmatech Inc. 发明人 Sharma Sanjay K.;Woo Thomas;Naicker Selvaraj
分类号 A61K49/00;A61B5/00;A61B8/00;A61B10/00 主分类号 A61K49/00
代理机构 Benoît & Côté Inc. 代理人 Benoît & Côté Inc.
主权项 1. A compound of formula (IIIa) or (IIIb) or stereoisomer or atropisomer thereof:wherein T is a —CH2—; R4 and R5 are independently hydrogen, deuterium, hydroxy, oxygen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aryl, C6-C12 aralkyl, C1-C12 heterocyclyl, C1-C12 heteroaryl, —COR1, —(CH2)mOR1, —CO2H, —CO2R1, —C(O)N(R1)2, —C(O)NH(R1), —C(O)NH2 or an amino suitable protecting group, said C1-C4 alkylenyl, C2-C4 alkenylenyl, C1-C4 heteroalkylenyl, C2-C4 heteroalkenylenyl, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aryl, C6-C12 aralkyl, C1-C12 heterocyclyl, and C1-C12 heteroaryl being unsubstituted or substituted with at least one substituent selected from the group consisting of a halogen atom, hydroxy, carboxy, thiol, azide, nitro, C1-C8 deuterated alkyl group comprising at least one deuterated atom, —COH, —COR1, —(CH2)mOR1, —CO2H, —CO2R1, —C(O)N(R1)2, —C(O)NH(R1), —C(O)NH2, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aryl, C6-C12 aralkyl, C1-C12 heterocyclyl and C1-C12 heteroaryl; R1 is a hydrogen atom, C1-C8 alkyl, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aralkyl, or C1-C12 heterocyclyl; each R2 is independently a hydrogen atom, C1-C8 alkyl, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aralkyl, or C1-C12 heterocyclyl; p has a value of 4 so that ring A is a six-membered ring; R6 is hydrogen; and R7 is hydrogen; m is an integer having a value of 1 to 13,or a pharmaceutically acceptable salt thereof.
地址 Edmonton CA