主权项 |
1. A compound of formula (IIIa) or (IIIb) or stereoisomer or atropisomer thereof:wherein
T is a —CH2—; R4 and R5 are independently hydrogen, deuterium, hydroxy, oxygen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aryl, C6-C12 aralkyl, C1-C12 heterocyclyl, C1-C12 heteroaryl, —COR1, —(CH2)mOR1, —CO2H, —CO2R1, —C(O)N(R1)2, —C(O)NH(R1), —C(O)NH2 or an amino suitable protecting group, said C1-C4 alkylenyl, C2-C4 alkenylenyl, C1-C4 heteroalkylenyl, C2-C4 heteroalkenylenyl, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aryl, C6-C12 aralkyl, C1-C12 heterocyclyl, and C1-C12 heteroaryl being unsubstituted or substituted with at least one substituent selected from the group consisting of a halogen atom, hydroxy, carboxy, thiol, azide, nitro, C1-C8 deuterated alkyl group comprising at least one deuterated atom, —COH, —COR1, —(CH2)mOR1, —CO2H, —CO2R1, —C(O)N(R1)2, —C(O)NH(R1), —C(O)NH2, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aryl, C6-C12 aralkyl, C1-C12 heterocyclyl and C1-C12 heteroaryl; R1 is a hydrogen atom, C1-C8 alkyl, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aralkyl, or C1-C12 heterocyclyl; each R2 is independently a hydrogen atom, C1-C8 alkyl, C3-C8 cycloalkyl, C4-C10 cycloalkenyl, C6-C12 aralkyl, or C1-C12 heterocyclyl; p has a value of 4 so that ring A is a six-membered ring; R6 is hydrogen; and R7 is hydrogen; m is an integer having a value of 1 to 13,or a pharmaceutically acceptable salt thereof.
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